Impact of Vancomycin Serum Trough Concentrations and Vancomycin AUC/MIC on Vancomycin Response, In-Hospital Outcomes and Acute Kidney Injury in Pediatric Staphylococcus aureus Pneumonia
نویسندگان
چکیده
82. The Association of Molecular Characteristics, Vancomycin MIC and Clinical Outcomes in Methicillin-susceptible Staphylococcus aureus Osteoarticular Infections in Children Jonathon McNeil, MD; Jesus G. Vallejo, MD, FIDSA; Louie Rosas, BS; Edward O. Mason Jr., PhD, FIDSA; Sheldon L. Kaplan, MD, FIDSA; Kristina G. Hulten, PhD; Pediatrics, Baylor College of Medicine, Houston, Texas; Pediatrics, Baylor College of Medicine and Texas Children’s Hospital, Houston, Texas; Baylor College of Medicine and Texas Children’s Hospital, Houston, Texas
منابع مشابه
Is peak concentration needed in therapeutic drug monitoring of vancomycin? A pharmacokinetic-pharmacodynamic analysis in patients with methicillin-resistant staphylococcus aureus pneumonia.
BACKGROUND We analyzed the pharmacokinetic-pharmacodynamic relationship of vancomycin to determine the drug exposure parameters that correlate with the efficacy and nephrotoxicity of vancomycin in patients with methicillin-resistant Staphylococcus aureus pneumonia and evaluated the need to use peak concentration in therapeutic drug monitoring (TDM). METHODS Serum drug concentrations of 31 hos...
متن کاملA Prospective Study to Assess Vancomycin Serum Concentrations in Pediatric Patients with Current Dosing Guidelines
Concerns about increasing bacterial resistance to vancomycin, have caused the adult treatment guidelines to recommend higher trough concentrations based on the type and location of infectious disease. Although these recommendations are not specific to children, the values can be extrapolated. This prospective study was designed to evaluate efficacy of current vancomycin dosing recommendations t...
متن کاملVancomycin AUC/MIC ratio and 30-day mortality in patients with Staphylococcus aureus bacteremia.
A ratio of the vancomycin area under the concentration-time curve to the MIC (AUC/MIC) of ≥ 400 has been associated with clinical success when treating Staphylococcus aureus pneumonia, and this target was recommended by recently published vancomycin therapeutic monitoring consensus guidelines for treating all serious S. aureus infections. Here, vancomycin serum trough levels and vancomycin AUC/...
متن کاملA Prospective Study to Assess Vancomycin Serum Concentrations in Pediatric Patients with Current Dosing Guidelines
Concerns about increasing bacterial resistance to vancomycin, have caused the adult treatment guidelines to recommend higher trough concentrations based on the type and location of infectious disease. Although these recommendations are not specific to children, the values can be extrapolated. This prospective study was designed to evaluate efficacy of current vancomycin dosing recommendations t...
متن کاملHigh-dose vancomycin therapy for methicillin-resistant Staphylococcus aureus infections: efficacy and toxicity.
BACKGROUND Vancomycin hydrochloride treatment failure for infections caused by susceptible methicillin-resistant Staphylococcus aureus (MRSA) strains with high minimum inhibitory concentration (MIC) has prompted recent guidelines to recommend a higher vancomycin target trough of 15 to 20 microg/mL. METHODS A prospective cohort study of adult patients infected with MRSA was performed to determ...
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2017